| July |
| L | Sat 3/7/2010 | Frdly | Parkhouse |  | 3-2 |  | Shirebrook Town | Att: 96 |
| L | Sat 24/7/2010 | Frdly | Shirebrook Town |  | 0-5 |  | Worksop Town | |
| L | Tue 27/7/2010 | Frdly | Shirebrook Town |  | 1-2 |  | Belper Town | |
| L | Sat 31/7/2010 | Frdly | Shirebrook Town |  | 0-3 |  | Borrowash Victoria | |
| August |
| W | Sat 7/8/2010 | NCEL1 | Shirebrook Town Sean Hamstead 4 Ben Bowring 26 Simon Johnson 35, 57 Simon Hore 85 |  | 5-3 |  | Appleby Frodingham Paul Reilly 3 Steve McCarron 65 Lee Woods 87 | Att: 91 HT: 3-1 |
| W | Sat 14/8/2010 | FACEP | Rossington Main |  | 0-3 |  | Shirebrook Town Simon Johnson 8pen, 11pen, 64 | Att: 75 HT: 0-2 |
| L | Sat 21/8/2010 | NCEL1 | Shirebrook Town Peter Stubley 50 |  | 1-3 |  | Glasshoughton Welfare Mark Newton 42 Dell Pollock 46 Tim Edney 79 | Att: 83 HT: 0-1 |
| L | Wed 25/8/2010 | NCEL1 | Shirebrook Town Tim Bradley 55 |  | 1-3 |  | Leeds Carnegie Greig McGrory 5 Marco Marchetta 70pen Scott McGrory 86 | Att: 65 HT: 0-1 |
| W | Sat 28/8/2010 | FACP | Barton Town Old Boys Ashley Dexter 50 |  | 1-4 |  | Shirebrook Town Simon Johnson 19 Tim Bradley 27 Peter Stubley 47 Gareth Davey 77 | Att: 83 HT: 0-2 |
| W | Mon 30/8/2010 | NCEL1 | Shirebrook Town Simon Hore 16 Peter Stubley 28 |  | 2-1 |  | Grimsby Borough Lee Stephenson 39 | Att: 106 HT: 2-1 |
| September |
| L | Sat 4/9/2010 | FAV1Q | Blackstones Andrew Boome 4 David Burton-Jones 30 |  | 2-0 |  | Shirebrook Town | Att: 84 HT: 2-0 |
| D | Wed 8/9/2010 | NCEL1 | Shirebrook Town Michael Lyall 62 |  | 1-1 |  | Eccleshill United Marcus Edwards 3 | Att: 52 HT: 0-1 |
| L | Sat 11/9/2010 | FAC1Q | Shirebrook Town Simon Johnson 56pen |  | 1-3 |  | Lincoln United Sam Wilkinson 14 Steve Melton 19 Sam Maculkey 45 | Att: 119 HT: 0-3 |
| W | Sat 18/9/2010 | NCEL1 | Shirebrook Town Sean Dickinson 42 Michael Lyall 72, 76 |  | 3-0 |  | Teversal | Att: 92 HT: 1-0 |
| L | Wed 22/9/2010 | NCEL1 | Staveley Miners Welfare Aymen Tahar 33 Ryan Damms 37pen Christopher Coy 83 |  | 3-1 |  | Shirebrook Town Simon Johnson 22pen | Att: 122 HT: 2-1 |
| L | Sat 25/9/2010 | NCEL1 | Yorkshire Amateur Curtis Bernard 35, 42 Fernando Moke 54 Justin Bowler 71 |  | 4-1 |  | Shirebrook Town Michael Lyall 31 | Att: 31 HT: 2-1 |
| October |
| W | Sat 2/10/2010 | NCEL1 | Shirebrook Town Simon Johnson 56, 83 Michael Lyall 75 |  | 3-0 |  | Brodsworth Welfare | Att: 75 HT: 0-0 |
| D | Wed 6/10/2010 | NCEL1 | Askern Villa Mark Vickerage 26, 61 |  | 2-2 |  | Shirebrook Town Sean Dickinson 18 Michael Lyall 58 | Att: 36 HT: 1-1 |
| L | Sat 9/10/2010 | NCEL1 | Bottesford Town Carl La Rocca 5 Phil Doyle 70pen, 89 |  | 3-1 |  | Shirebrook Town Jordan Johnson 58 | Att: 69 HT: 1-0 |
| W | Sat 16/10/2010 | NCEL1 | Shirebrook Town Peter Stubley 58, 80, 85 |  | 3-1 |  | Hemsworth Miners Welfare Craig Wilkinson 33 | Att: 78 HT: 0-1 |
| W | Wed 20/10/2010 | WST1 | Appleby Frodingham |  | 0-3 |  | Shirebrook Town Simon Welton 25og Sean Dickinson 26 Simon Johnson 68 | Att: 30 HT: 0-2 |
| L | Sat 23/10/2010 | NCEL1 | Barton Town Old Boys Gareth Barlow 2 Adam Crane 48 Richard Medcalf 61 |  | 3-2 |  | Shirebrook Town Simon Johnson 47 Gareth Davey 70 | Att: 102 HT: 1-0 |
| L | Tue 26/10/2010 | LC1 | Louth Town Sam Smith 8, 36 Kurt Crossley 10, 79, 90 Mark Fairburn 37 Danny Kilmore 47pen Tim Lowe 86 |  | 8-0 |  | Shirebrook Town | Att: 60 HT: 4-0 |
| L | Sat 30/10/2010 | NCEL1 | Shirebrook Town Lee Rhodes 70 |  | 1-3 |  | Louth Town Sam Smith 21 Danny Kilmore 52pen Jack Debnam 69 | Att: 73 HT: 0-1 |
| November |
| W | Wed 3/11/2010 | NCEL1 | Shirebrook Town Lee Rhodes 40 Sean Hamstead 51 Sean Dickinson 54 Michael Lyall 58 Ben Bowring 75 |  | 5-2 |  | Worsbrough Bridge Athletic Dean Shirt 60 Florent Fadiga 85 | Att: 71 HT: 1-0 |
| D | Sat 6/11/2010 | NCEL1 | Pontefract Collieries Craig Stephens 60, 70 Luke Smith 88pen |  | 3-3 |  | Shirebrook Town Sean Hamstead 11 Michael Lyall 13, 42 | Att: 64 HT: 0-3 |
| W | Wed 10/11/2010 | NCEL1 | Appleby Frodingham Thomas Finnigan 17, 33 |  | 2-3 |  | Shirebrook Town Danny Briggs 4 Michael Lyall 15 Gareth Campion 80 | Att: 25 HT: 2-2 |
| W | Sat 13/11/2010 | DSC2 | Newhall United Lee Harrison 15 |  | 1-3 |  | Shirebrook Town Michael Lyall 4 Ben Bowring 9 Kurt Angel 82 | Att: 30 HT: 1-2 |
| L | Wed 17/11/2010 | NCEL1 | Shirebrook Town Michael Lyall 32 |  | 1-2 |  | Rossington Main Jason Stokes 24 Michael MacDonald 58 | Att: 58 HT: 1-1 |
| L | Sat 20/11/2010 | NCEL1 | Handsworth David Cockerill 14 Ryan Johnson 36 |  | 2-1 |  | Shirebrook Town Michael Lyall 42 | Att: 84 HT: 2-1 |
| December |
| L | Wed 15/12/2010 | WST2 | AFC Emley Steve Kenworthy 90 Mark Stuart 105 |  | 2-1 (aet) |  | Shirebrook Town Michael Lyall 51 | Att: 78 HT: 0-0 90: 1-1 |
| (AFC Emley removed from competition for fielding ineligible player - Shirebrook Town reinstated) |
| January |
| D | Mon 3/1/2011 | NCEL1 | Teversal Mitchell Slawson 14 |  | 1-1 |  | Shirebrook Town Michael Lyall 27 | Att: 143 HT: 1-1 |
| L | Wed 5/1/2011 | DSC3 | Derby County Ben Pringle 18, 36 Dave Martin 21 Jeff Hendrick 27, 69, 72 Tomasz Cywka 28, 33 Miles Addison 34 Steven Davies 36 Gareth Davey 48og Callum Ball 77, 80 Alex Witham 85 |  | 14-1 |  | Shirebrook Town Danny Briggs 1 | Att: 210 HT: 8-1 |
| (at Belper Town FC) |
| W | Sat 8/1/2011 | NCEL1 | Shirebrook Town Richard Guest 35 Simon Johnson 48pen |  | 2-1 |  | AFC Emley Teo Ringrose 28 | Att: 128 HT: 1-1 |
| L | Wed 12/1/2011 | NCEL1 | Shirebrook Town Simon Johnson 76pen |  | 1-3 |  | Staveley Miners Welfare Tom Jones 3 Ryan Damms 25pen Christopher Coy 70 | Att: 146 HT: 0-2 |
| L | Wed 19/1/2011 | NCEL1 | AFC Emley Dean Wharam 38, 43, 87 |  | 3-2 |  | Shirebrook Town Michael Lyall 17 Dean Cropper 62 | Att: 80 HT: 2-1 |
| W | Sat 22/1/2011 | NCEL1 | Grimsby Borough Luke Mascall 60 |  | 1-2 |  | Shirebrook Town Simon Johnson 25pen, 80pen | Att: 63 HT: 0-1 |
| February |
| W | Sat 5/2/2011 | NCEL1 | Shirebrook Town Peter Stubley 38 Darren Bettison 51 |  | 2-1 |  | Askern Villa Jay Rollins 75 | Att: 88 HT: 1-0 |
| W | Sat 12/2/2011 | NCEL1 | Eccleshill United Joe Penn 7 |  | 1-2 |  | Shirebrook Town Simon Johnson 10 Darren Bettison 79 | Att: 45 HT: 1-1 |
| L | Mon 28/2/2011 | NCEL1 | Leeds Carnegie Greig McGrory 26 Liam Smith 68 Kyle Hawthorne 74 |  | 3-2 |  | Shirebrook Town Simon Johnson 4 Ben Bowring 52 | Att: 47 HT: 1-1 |
| March |
| L | Sat 5/3/2011 | NCEL1 | Shirebrook Town Jeremy Mitchell 17 |  | 1-3 |  | Yorkshire Amateur Chris Hitchins 45pen Leroy McIntosh 54 Curtis Bernard 69 | Att: 82 HT: 1-1 |
| L | Wed 9/3/2011 | NCEL1 | Shirebrook Town Matt Draper 75 |  | 1-2 |  | Pontefract Collieries Carl Fothergill 63 Luke Smith 80pen | Att: 52 HT: 0-0 |
| W | Sat 12/3/2011 | NCEL1 | Brodsworth Welfare Sam Kirk 60 |  | 1-2 |  | Shirebrook Town Robbie Clarke 7 Anthony Bedward 66 | Att: 35 HT: 0-1 |
| L | Wed 16/3/2011 | WST3 | Shirebrook Town Joe Naylor 62pen, 74pen |  | 2-3 (aet) |  | Louth Town Bruno Holden 47, 86, 100 | Att: 91 HT: 0-0 90: 2-2 |
| W | Sat 19/3/2011 | NCEL1 | Shirebrook Town Joe Naylor 3, 8 |  | 2-1 |  | Bottesford Town Gareth Campion 33 | Att: 110 HT: 2-1 |
| W | Sat 26/3/2011 | NCEL1 | Hemsworth Miners Welfare |  | 0-2 |  | Shirebrook Town Joe Naylor 6 Peter Stubley 48 | Att: 125 HT: 0-1 |
| W | Tue 29/3/2011 | NCEL1 | Glasshoughton Welfare |  | 0-1 |  | Shirebrook Town Michael Lyall 21 | Att: 65 HT: 0-1 |
| April |
| L | Sat 2/4/2011 | NCEL1 | Shirebrook Town |  | 0-1 |  | Barton Town Old Boys Gareth Barlow 90 | Att: 64 HT: 0-0 |
| L | Tue 5/4/2011 | NCEL1 | Worsbrough Bridge Athletic Tom Copping 62 |  | 1-0 |  | Shirebrook Town | Att: 31 HT: 0-0 |
| L | Sat 9/4/2011 | NCEL1 | Louth Town Jack Debnam 21, 35pen Bruno Holden 44 Jamie Coulson 85 |  | 4-1 |  | Shirebrook Town Richard Guest 40 | Att: 70 HT: 3-1 |
| W | Sat 23/4/2011 | NCEL1 | Rossington Main Lee Holmes 19 |  | 1-2 |  | Shirebrook Town Lewis Jackson 39 Richard Guest 52 | Att: 68 HT: 1-1 |
| L | Sat 30/4/2011 | NCEL1 | Shirebrook Town Peter Stubley 84 |  | 1-3 |  | Handsworth Alex Torr 7, 8 Adam Fretwell 76 | Att: 162 HT: 0-2 |